Symbol
Name
ID

Irs2
insulin receptor substrate 2
MGI:109334

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus
Disease(s) Associated with IRS2	Type II diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes

decreased granulosa cell proliferation

abnormal pancreatic beta cell morphology

decreased pancreatic beta cell mass

increased pancreatic beta cell mass

decreased pancreatic beta cell number

small pancreatic islets

decreased gonadotroph cell number

small pituitary gland

small pituitary intermediate lobe

abnormal corpus luteum morphology

absent corpus luteum

abnormal ovarian follicle morphology

absent mature ovarian follicles

decreased primary ovarian follicle number

decreased tertiary ovarian follicle number

increased atretic ovarian follicle number

abnormal ovarian folliculogenesis

impaired ovarian folliculogenesis

polyovular ovarian follicle

small ovary

increased insulin secretion

Availability

Mouse Genotype

Irs2^M1Btlr/Irs2^M1Btlr

Irs2^tm1.1With/Irs2^tm1.1With

Irs2^tm1Mfw/Irs2^tm1Mfw
Tg(Ins2-Irs2)13Mfw/0

Irs2^tm1Mfw/Irs2^tm1Mfw

Irs2^tm1Tka/Irs2^tm1Tka

Tg(Ins2-Irs2)13Mfw/0

Irs2^tm1With/Irs2^tm1With
Tg(Ins2-cre)25Mgn/0 (conditional)

Irs2^tm1With/Irs2^tm1With
Tg(Nes-cre)1Kln/0 (conditional)

Irs2^tm2Mfw/Irs2^tm2Mfw
Tg(Ins2-cre)25Mgn/0 (conditional)

Irs2^tm2Tka/Irs2^tm2Tka
Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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